Spank, I live in a high hot desert area where the temps will run very high in the summer.
So quite often i will run my pc open on one side, while running and gunning in the games.
I use a a 8 inch fan blowing directly into the open side to maintain lower temps inside.YOU MUST KEEP ALL FAN BLADES CLEAN at all times.
I am sure you know all this listed below.
UNPLUG, disconnect any and all power cords, devices that are connected to computer prior to cleaning.
Granted anytime you run with the side open there are added risks and you must stay on top of cleaning and blowing the increase accumulation of dust and dirt out...(canned AIR is recommended and a long reach paint brush).
If you have any furry pets...(cats) Hair can be a big problem... I have 5 cats.
Cleaning is the key here.
I have been doing this for years , knock on wood without any problems.
You can always add another fan as and additional option.
I would suggest replacing any suspect fans....(cheap insurance).